In early January, BiotecEra received the second National Science Foundation (NSF) STTR Phase I Award. This fund will support the development of a novel microbial approach for the production a anticoagulant precursor 4-hydroxycoumarin (4-HC).
4-HC is a direct synthetic precursor used to manufacture widely used oral anticoagulants, such as warfarin, acenocoumarol, and phenprocoumon. In addition, 4-HC-derived anticoagulants are commonly used as rodenticides to kill rodents. Traditionally, 4-HC is commercially manufactured through chemical synthesis using petro-related aromatic chemicals as starting materials, which is neither economical nor environmentally friendly. The proposed technology to be developed in this project is expected to dramatically lower the production cost, and reduce the reliance on petro chemicals.